Delta_Delta가 0보다 현저히 증가하는 것은 보통 다음 경우임:

• mixed high anion gap metabolic acidosis + primary metaboloc alkalosis.
• mixed high anion gap metabolic acidosis + chronic respiratory acidosis.
• non-acidotic high anion gap 상태 (예-penicillin 과량 투여 등)

Delta_Delta가 0보다 현저히 작은 경우는 다음 경우에 의한 것일 수 있음:

• mixed high anion gap metabolic acidosis + normal anion gap metabolic acidosis.
• high anion gap metabolic acidosis + chronic respiratory alkalosis + hyperchloremia acidosis의 혼합
• high anion gap acidosis with a prexisting low anion gap state (예-hypoalbuminemia, para-proteinemia, 등등...)

참고문헌

Wrenn K, The delta (delta) gap: an approach to mixed acid-base disorders, Ann Emerg Med, 1990 Nov;19(11):1310-3

Breyer JA, Acid base course material, 6th National Critical Care Medicine Review Course